人 MUTYH (NM_001048173) cDNA克隆

基本信息

Accession: NM_001048173
基因名称: MUTYH
基因别名: MYH; CYP2C
基因描述: Homo sapiens mutY homolog (MUTYH), transcript variant gamma3, mRNA.
种属: Human
CDS区长度: 1566 (查看编码区序列)
翻译后氨基酸长度: 521 (查看氨基酸序列)
Transcript Variant: This variant (gamma3) contains a distinct 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. These differences cause translation initiation at a downstream start codon and result in a protein (isoform 4) that is shorter than isoform 5. Variants gamma3 and beta3 encode the same isoform, which has been shown to localize to the nucleus.

订购信息

产品编号 产品名称 载体 规格 价格
G113551 人 MUTYH (NM_001048173) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MUTYH (NM_012222) cDNA克隆 transcript variant alpha1
人 MUTYH (NM_001048171) cDNA克隆 transcript variant alpha3
人 MUTYH (NM_001128425) cDNA克隆 transcript variant alpha5
人 MUTYH (NM_001048174) cDNA克隆 transcript variant beta3
人 MUTYH (NM_001048172) cDNA克隆 transcript variant gamma2
人 MUTYH (NM_001048173) cDNA克隆 transcript variant gamma3

基因简介

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

相关产品