人 RUNX1T1 (NM_004349) cDNA克隆

Accession: NM_004349
基因名称: RUNX1T1
基因别名: CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1
基因描述: Homo sapiens runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1734 (查看编码区序列)
翻译后氨基酸长度: 577 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes isoform A. Variants 1, 5 and 6 all encode isoform A, also known as MTG8a.
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G113581 人 RUNX1T1 (NM_004349) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]