人 TOP3B (NM_001282113) cDNA克隆

Accession: NM_001282113
基因名称: TOP3B
基因别名: TOP3B1
基因描述: Homo sapiens topoisomerase (DNA) III beta (TOP3B), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2589 (查看编码区序列)
翻译后氨基酸长度: 862 (查看氨基酸序列)
Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
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G114051 人 TOP3B (NM_001282113) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]