人 AKTIP (NM_001012398) cDNA克隆

Accession: NM_001012398
基因名称: AKTIP
基因别名: FT1; FTS
基因描述: Homo sapiens AKT interacting protein (AKTIP), transcript variant 1, mRNA.
种属: Human
CDS区长度: 879 (查看编码区序列)
翻译后氨基酸长度: 292 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
产品编号 产品名称 载体 规格 价格
G114831 人 AKTIP (NM_001012398) cDNA克隆 pDONR223 2ug质粒 点击询价

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]