人 GPX4 (NM_001039847) cDNA克隆

基本信息

Accession: NM_001039847
基因名称: GPX4
基因别名: MCSP; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx
基因描述: Homo sapiens glutathione peroxidase 4 (GPX4), transcript variant 2, mRNA.
种属: Human
CDS区长度: 684 (查看编码区序列)
翻译后氨基酸长度: 227 (查看氨基酸序列)
Transcript Variant: This variant (2) uses a frame-shifting alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (B) is longer and has a distinct C-terminus, compared to isoform A. Whether alternate transcription initiation sites exist in variant 2, such that two forms of isoform B are produced, needs to be experimentally verified.

订购信息

产品编号 产品名称 载体 规格 价格
G115372 人 GPX4 (NM_001039847) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 GPX4 (NM_002085) cDNA克隆 transcript variant 1
人 GPX4 (NM_001039847) cDNA克隆 transcript variant 2
人 GPX4 (NM_001039848) cDNA克隆 transcript variant 3

基因简介

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq, Jul 2008]

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