人 SKIL (NM_001145097) cDNA克隆

基本信息

Accession: NM_001145097
基因名称: SKIL
基因别名: SNO; SnoA; SnoI; SnoN
基因描述: Homo sapiens SKI-like oncogene (SKIL), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1917 (查看编码区序列)
翻译后氨基酸长度: 638 (查看氨基酸序列)
Transcript Variant: This variant (2, also known as SnoN2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G115664 人 SKIL (NM_001145097) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SKIL (NM_005414) cDNA克隆 transcript variant 1
人 SKIL (NM_001145097) cDNA克隆 transcript variant 2
人 SKIL (NM_001145098) cDNA克隆 transcript variant 3
人 SKIL (NM_001248008) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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