人 HERC4 (NM_001278186) cDNA克隆

基本信息

Accession: NM_001278186
基因名称: HERC4
基因描述: Homo sapiens HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HERC4), transcript variant 4, mRNA.
种属: Human
CDS区长度: 2385 (查看编码区序列)
翻译后氨基酸长度: 794 (查看氨基酸序列)
Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1, and one causes a frameshift. These differences cause translation initiation at a downstream AUG and result in an isoform (d) with a shorter and distinct N-terminus and lacking an alternate internal segment, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G115868 人 HERC4 (NM_001278186) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 HERC4 (NM_022079) cDNA克隆 transcript variant 1
人 HERC4 (NM_015601) cDNA克隆 transcript variant 2
人 HERC4 (NM_001278185) cDNA克隆 transcript variant 3
人 HERC4 (NM_001278186) cDNA克隆 transcript variant 4
人 HERC4 (NM_001278187) cDNA克隆 transcript variant 5

基因简介

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

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