This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
人 MMP19 (NM_001272101) cDNA克隆
| Accession: | NM_001272101 |
|---|---|
| 基因名称: | MMP19 |
| 基因别名: | MMP18; RASI-1 |
| 基因描述: | Homo sapiens matrix metallopeptidase 19 (MMP19), transcript variant 3, mRNA. |
| 种属: | Human |
| CDS区长度: | 918 (查看编码区序列) |
| 翻译后氨基酸长度: | 305 (查看氨基酸序列) |
| Transcript Variant: | This variant (3) contains multiple differences in the coding region, compared to variant 1, one of which results in a frameshift. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. |
| 人 MMP19 (NM_002429) cDNA克隆 | transcript variant 1 |
| 人 MMP19 (NM_001272101) cDNA克隆 | transcript variant 3 |
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