人 CD74 (NM_001025158) cDNA克隆

基本信息

Accession: NM_001025158
基因名称: CD74
基因别名: II; DHLAG; HLADG; Ia-GAMMA
基因描述: Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 3, mRNA.
种属: Human
CDS区长度: 483 (查看编码区序列)
翻译后氨基酸长度: 160 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks three consecutive exons in the 3' coding region, which results in a frame-shift, compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus, compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G117612 人 CD74 (NM_001025158) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CD74 (NM_001025159) cDNA克隆 class II invariant chain (CD74)transcript variant 1
人 CD74 (NM_004355) cDNA克隆 class II invariant chain (CD74)transcript variant 2
人 CD74 (NM_001025158) cDNA克隆 class II invariant chain (CD74)transcript variant 3

基因简介

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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