人 MVB12B (NM_001011703) cDNA克隆

基本信息

Accession: NM_001011703
基因名称: MVB12B
基因别名: C9orf28; FAM125B
基因描述: Homo sapiens multivesicular body subunit 12B (MVB12B), transcript variant 2, mRNA.
种属: Human
CDS区长度: 666 (查看编码区序列)
翻译后氨基酸长度: 221 (查看氨基酸序列)
Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G117629 人 MVB12B (NM_001011703) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MVB12B (NM_033446) cDNA克隆 transcript variant 1
人 MVB12B (NM_001011703) cDNA克隆 transcript variant 2

基因简介

The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

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