人 TNNI2 (NM_001145841) cDNA克隆

Accession: NM_001145841
基因名称: TNNI2
基因别名: DA2B; FSSV; fsTnI; AMCD2B
基因描述: Homo sapiens troponin I type 2 (skeletal, fast) (TNNI2), transcript variant 3, mRNA.
种属: Human
CDS区长度: 549 (查看编码区序列)
翻译后氨基酸长度: 182 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks a few of 5' exons, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is the same size but has a different N-terminus, as compared to isoform 1.
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G117653 人 TNNI2 (NM_001145841) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]