人 SNCA (NM_007308) cDNA克隆

基本信息

Accession: NM_007308
基因名称: SNCA
基因别名: PD1; NACP; PARK1; PARK4
基因描述: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA.
种属: Human
CDS区长度: 339 (查看编码区序列)
翻译后氨基酸长度: 112 (查看氨基酸序列)
Transcript Variant: This variant (4, also known as NACP112) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (NACP112) has the same N- and C-termini but is shorter compared to isoform NACP140.

订购信息

产品编号 产品名称 载体 规格 价格
G118378 人 SNCA (NM_007308) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SNCA (NM_000345) cDNA克隆 transcript variant 1
人 SNCA (NM_001146054) cDNA克隆 transcript variant 2
人 SNCA (NM_001146055) cDNA克隆 transcript variant 3
人 SNCA (NM_007308) cDNA克隆 transcript variant 4

基因简介

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

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