人 LATS1 (NM_001270519) cDNA克隆

Accession: NM_001270519
基因名称: LATS1
基因别名: wts; WARTS
基因描述: Homo sapiens large tumor suppressor kinase 1 (LATS1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2073 (查看编码区序列)
翻译后氨基酸长度: 690 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks the last four exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
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G119167 人 LATS1 (NM_001270519) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]