人 AANAT (NM_001088) cDNA克隆

Accession: NM_001088
基因名称: AANAT
基因别名: DSPS; SNAT
基因描述: Homo sapiens aralkylamine N-acetyltransferase (AANAT), transcript variant 2, mRNA.
种属: Human
CDS区长度: 624 (查看编码区序列)
翻译后氨基酸长度: 207 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
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G119478 人 AANAT (NM_001088) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]