人 MADD (NM_130470) cDNA克隆

Accession: NM_130470
基因名称: MADD
基因别名: DENN; IG20; RAB3GEP
基因描述: Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 1, mRNA.
种属: Human
CDS区长度: 4767 (查看编码区序列)
翻译后氨基酸长度: 1588 (查看氨基酸序列)
Transcript Variant: This variant (1) has a different exon 1 sequence and lacks exons 16, 21 and 26, as compared to transcript variant 4. The resulting isoform (a) is shorter than isoform d.
产品编号 产品名称 载体 规格 价格
G120822 人 MADD (NM_130470) cDNA克隆 pDONR223 2ug质粒 点击询价
人 MADD (NM_130470) cDNA克隆 transcript variant 1
人 MADD (NM_001135944) cDNA克隆 transcript variant 10
人 MADD (NM_130471) cDNA克隆 transcript variant 2
人 MADD (NM_130472) cDNA克隆 transcript variant 3
人 MADD (NM_003682) cDNA克隆 transcript variant 4
人 MADD (NM_130473) cDNA克隆 transcript variant 5
人 MADD (NM_130474) cDNA克隆 transcript variant 6
人 MADD (NM_130475) cDNA克隆 transcript variant 7
人 MADD (NM_130476) cDNA克隆 transcript variant 8
人 MADD (NM_001135943) cDNA克隆 transcript variant 9

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]