人 RBFOX1 (NM_001142334) cDNA克隆

基本信息

Accession: NM_001142334
基因名称: RBFOX1
基因别名: 2BP1; FOX1; A2BP1; FOX-1; HRNBP1
基因描述: Homo sapiens RNA binding protein, fox-1 homolog (C. elegans) 1 (RBFOX1), transcript variant 6, mRNA.
种属: Human
CDS区长度: 1194 (查看编码区序列)
翻译后氨基酸长度: 397 (查看氨基酸序列)
Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4.

订购信息

产品编号 产品名称 载体 规格 价格
G121901 人 RBFOX1 (NM_001142334) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RBFOX1 (NM_145891) cDNA克隆 transcript variant 1
人 RBFOX1 (NM_145892) cDNA克隆 transcript variant 2
人 RBFOX1 (NM_145893) cDNA克隆 transcript variant 3
人 RBFOX1 (NM_018723) cDNA克隆 transcript variant 4
人 RBFOX1 (NM_001142333) cDNA克隆 transcript variant 5
人 RBFOX1 (NM_001142334) cDNA克隆 transcript variant 6

基因简介

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

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