人 IL6ST (NM_175767) cDNA克隆

基本信息

Accession: NM_175767
基因名称: IL6ST
基因别名: CD130; GP130; CDW130; IL-6RB
基因描述: Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 2, mRNA.
种属: Human
CDS区长度: 990 (查看编码区序列)
翻译后氨基酸长度: 329 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an alternate internal exon, which results in a frameshift in the 3' coding region and a premature termination codon, compared to variant 1. The resulting isoform (2, also known as gp130-RAPS) has a distinct and shorter C-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G122284 人 IL6ST (NM_175767) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 IL6ST (NM_002184) cDNA克隆 transcript variant 1
人 IL6ST (NM_175767) cDNA克隆 transcript variant 2
人 IL6ST (NM_001190981) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010]

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