人 TP73 (NM_005427) cDNA克隆

Accession: NM_005427
基因名称: TP73
基因别名: P73
基因描述: Homo sapiens tumor protein p73 (TP73), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1911 (查看编码区序列)
翻译后氨基酸长度: 636 (查看氨基酸序列)
Transcript Variant: This variant (1), encodes isoform a, also known as TA p73 alpha.
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G122352 人 TP73 (NM_005427) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]