人 KCNH1 (NM_172362) cDNA克隆

Accession: NM_172362
基因名称: KCNH1
基因别名: EAG; EAG1; h-eag; Kv10.1
基因描述: Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 2970 (查看编码区序列)
翻译后氨基酸长度: 989 (查看氨基酸序列)
Transcript Variant: This variant (1), also known as eagB, encodes the longer isoform (1).
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G122470 人 KCNH1 (NM_172362) cDNA克隆 pDONR223 2ug质粒 点击询价

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]