人 SUN2 (NM_015374) cDNA克隆

基本信息

Accession: NM_015374
基因名称: SUN2
基因别名: UNC84B
基因描述: Homo sapiens Sad1 and UNC84 domain containing 2 (SUN2), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2154 (查看编码区序列)
翻译后氨基酸长度: 717 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

订购信息

产品编号 产品名称 载体 规格 价格
G122902 人 SUN2 (NM_015374) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SUN2 (NM_001199579) cDNA克隆 transcript variant 1
人 SUN2 (NM_015374) cDNA克隆 transcript variant 2
人 SUN2 (NM_001199580) cDNA克隆 transcript variant 3

基因简介

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]

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