人 CSE1L (NM_001256135) cDNA克隆

基本信息

Accession: NM_001256135
基因名称: CSE1L
基因别名: CAS; CSE1; XPO2
基因描述: Homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2748 (查看编码区序列)
翻译后氨基酸长度: 915 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G124514 人 CSE1L (NM_001256135) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CSE1L (NM_001316) cDNA克隆 transcript variant 1
人 CSE1L (NM_001256135) cDNA克隆 transcript variant 2

基因简介

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

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