人 MTRR (NM_002454) cDNA克隆

基本信息

Accession: NM_002454
基因名称: MTRR
基因别名: MSR; cblE
基因描述: Homo sapiens 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), transcript variant 1, mRNA.
种属: Human
CDS区长度: 2097 (查看编码区序列)
翻译后氨基酸长度: 698 (查看氨基酸序列)
Transcript Variant: This variant (1) lacks sequence at the 5' end of exon 1 and has additional sequence at the 3' end of exon 1, as compared to transcript variant 2. This produces a downstream, in-frame translation start codon. Isoform 1 encoded by this variant is 27 aa shorter than the product of transcript variant 2.

订购信息

产品编号 产品名称 载体 规格 价格
G124563 人 MTRR (NM_002454) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MTRR (NM_002454) cDNA克隆 transcript variant 1
人 MTRR (NM_024010) cDNA克隆 transcript variant 2

基因简介

Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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