人 CHEK1 (NM_001114122) cDNA克隆

Accession: NM_001114122
基因名称: CHEK1
基因别名: CHK1
基因描述: Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1431 (查看编码区序列)
翻译后氨基酸长度: 476 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variant 1-3 encode the same isoform.
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G127774 人 CHEK1 (NM_001114122) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]