人 CCR3 (NM_001837) cDNA克隆

Accession: NM_001837
基因名称: CCR3
基因别名: CKR3; CD193; CMKBR3; CC-CKR-3
基因描述: Homo sapiens chemokine (C-C motif) receptor 3 (CCR3), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1068 (查看编码区序列)
翻译后氨基酸长度: 355 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longest transcript. It encodes the same isoform (1) as variant 2.
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G129292 人 CCR3 (NM_001837) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]