人 ADRA1B (NM_000679) cDNA克隆

Accession: NM_000679
基因名称: ADRA1B
基因别名: ADRA1; ALPHA1BAR
基因描述: Homo sapiens adrenoceptor alpha 1B (ADRA1B), mRNA.
种属: Human
CDS区长度: 1563 (查看编码区序列)
翻译后氨基酸长度: 520 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G131749 人 ADRA1B (NM_000679) cDNA克隆 pDONR223 2ug质粒 点击询价

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]