The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]
小鼠 Ldha (NM_001136069) cDNA克隆
| Accession: | NM_001136069 |
|---|---|
| 基因名称: | Ldha |
| 基因别名: | Ldh1; Ldhm; l7R2 |
| 基因描述: | Mus musculus lactate dehydrogenase A (Ldha), transcript variant 2, mRNA. |
| 种属: | Mouse |
| CDS区长度: | 1086 (查看编码区序列) |
| 翻译后氨基酸长度: | 361 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) uses an alternate 5' exon that results in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1. |
| 小鼠 Ldha (NM_010699) cDNA克隆 | transcript variant 1 |
| 小鼠 Ldha (NM_001136069) cDNA克隆 | transcript variant 2 |
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