人 MECOM (NM_004991) cDNA克隆

基本信息

Accession: NM_004991
基因名称: MECOM
基因别名: EVI1; MDS1; PRDM3; MDS1-EVI1; AML1-EVI-1
基因描述: Homo sapiens MDS1 and EVI1 complex locus (MECOM), transcript variant 4, mRNA.
种属: Human
CDS区长度: 3720 (查看编码区序列)
翻译后氨基酸长度: 1239 (查看氨基酸序列)
Transcript Variant: This variant (4, also known as MDS1/EVI1) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a. There are no publicly available full-length transcripts representing this variant, but it is supported by cloning evidence in PMID:11050005.

订购信息

产品编号 产品名称 载体 规格 价格
G137132 人 MECOM (NM_004991) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MECOM (NM_001105077) cDNA克隆 transcript variant 1
人 MECOM (NM_005241) cDNA克隆 transcript variant 2
人 MECOM (NM_001105078) cDNA克隆 transcript variant 3
人 MECOM (NM_004991) cDNA克隆 transcript variant 4
人 MECOM (NM_001163999) cDNA克隆 transcript variant 5
人 MECOM (NM_001164000) cDNA克隆 transcript variant 6
人 MECOM (NM_001205194) cDNA克隆 transcript variant 7

基因简介

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

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