人 APC (NM_001127510) cDNA克隆

基本信息

Accession: NM_001127510
基因名称: APC
基因别名: GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
基因描述: Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA.
种属: Human
CDS区长度: 8532 (查看编码区序列)
翻译后氨基酸长度: 2843 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2 and 3 encode the same isoform (b).

订购信息

产品编号 产品名称 载体 规格 价格
G149287 人 APC (NM_001127510) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 APC (NM_001127511) cDNA克隆 transcript variant 1
人 APC (NM_001127510) cDNA克隆 transcript variant 2
人 APC (NM_000038) cDNA克隆 transcript variant 3

基因简介

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

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