人 ACADVL (NM_001270448) cDNA克隆

基本信息

Accession: NM_001270448
基因名称: ACADVL
基因别名: ACAD6; LCACD; VLCAD
基因描述: Homo sapiens acyl-CoA dehydrogenase, very long chain (ACADVL), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1740 (查看编码区序列)
翻译后氨基酸长度: 579 (查看氨基酸序列)
Transcript Variant: This variant (4) has an additional segment in the 5' exon, compared to variant 1. The 5'-most supported initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, and result in an isoform (4), which is shorter at the N-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G150951 人 ACADVL (NM_001270448) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ACADVL (NM_000018) cDNA克隆 transcript variant 1
人 ACADVL (NM_001033859) cDNA克隆 transcript variant 2
人 ACADVL (NM_001270447) cDNA克隆 transcript variant 3
人 ACADVL (NM_001270448) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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