人 SMAD7 (NM_005904) cDNA克隆

基本信息

Accession: NM_005904
基因名称: SMAD7
基因别名: CRCS3; MADH7; MADH8
基因描述: Homo sapiens SMAD family member 7 (SMAD7), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1281 (查看编码区序列)
翻译后氨基酸长度: 426 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

订购信息

产品编号 产品名称 载体 规格 价格
G152306 人 SMAD7 (NM_005904) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SMAD7 (NM_005904) cDNA克隆 transcript variant 1
人 SMAD7 (NM_001190821) cDNA克隆 transcript variant 2
人 SMAD7 (NM_001190822) cDNA克隆 transcript variant 3
人 SMAD7 (NM_001190823) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

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