人 DACT1 (NM_016651) cDNA克隆

Accession: NM_016651
基因名称: DACT1
基因别名: DPR1; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1
基因描述: Homo sapiens dishevelled-binding antagonist of beta-catenin 1 (DACT1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 2511 (查看编码区序列)
翻译后氨基酸长度: 836 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longer isoform (1).
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G153922 人 DACT1 (NM_016651) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]