小鼠 Suz12 (NM_001163018) cDNA克隆

基本信息

Accession: NM_001163018
基因名称: Suz12
基因别名: AI195385; AU016842; AW536442; mKIAA0160; D11Ertd530e; RP23-253E9.4; 2610028O16Rik
基因描述: Mus musculus suppressor of zeste 12 homolog (Drosophila) (Suz12), transcript variant 2, mRNA.
种属: Mouse
CDS区长度: 2157 (查看编码区序列)
翻译后氨基酸长度: 718 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G154240 小鼠 Suz12 (NM_001163018) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

小鼠 Suz12 (NM_199196) cDNA克隆 transcript variant 1
小鼠 Suz12 (NM_001163018) cDNA克隆 transcript variant 2

基因简介

This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

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