人 SSH1 (NM_001161330) cDNA克隆

基本信息

Accession: NM_001161330
基因名称: SSH1
基因别名: SSH1L
基因描述: Homo sapiens slingshot protein phosphatase 1 (SSH1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2079 (查看编码区序列)
翻译后氨基酸长度: 692 (查看氨基酸序列)
Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2, also known as SSH-1S) with a distinct C-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G154806 人 SSH1 (NM_001161330) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SSH1 (NM_018984) cDNA克隆 transcript variant 1
人 SSH1 (NM_001161330) cDNA克隆 transcript variant 2
人 SSH1 (NM_001161331) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

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