The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
人 ARID4A (NM_023000) cDNA克隆
| Accession: | NM_023000 |
|---|---|
| 基因名称: | ARID4A |
| 基因别名: | RBP1; RBBP1; RBP-1; RBBP-1 |
| 基因描述: | Homo sapiens AT rich interactive domain 4A (RBP1-like) (ARID4A), transcript variant 2, mRNA. |
| 种属: | Human |
| CDS区长度: | 3612 (查看编码区序列) |
| 翻译后氨基酸长度: | 1203 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) lacks 162 bp in the coding region, as compared to variant 1, but maintains the same reading frame. The encoded protein lacks 54 internal codons and is thought to lack phosphorylation sites. |
| 人 ARID4A (NM_002892) cDNA克隆 | transcript variant 1 |
| 人 ARID4A (NM_023000) cDNA克隆 | transcript variant 2 |
| 人 ARID4A (NM_023001) cDNA克隆 | transcript variant 3 |
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