人 SCN4B (NM_001142349) cDNA克隆

基本信息

Accession: NM_001142349
基因名称: SCN4B
基因别名: LQT10; Navbeta4
基因描述: Homo sapiens sodium channel, voltage-gated, type IV, beta subunit (SCN4B), transcript variant 3, mRNA.
种属: Human
CDS区长度: 357 (查看编码区序列)
翻译后氨基酸长度: 118 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (3) which has a shorter N-terminus, compared to isoform 1. Translation initiation from the start codon 197 nucleotides upstream would subject the transcript to nonsense-mediated mRNA decay (NMD).

订购信息

产品编号 产品名称 载体 规格 价格
G157533 人 SCN4B (NM_001142349) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SCN4B (NM_174934) cDNA克隆 transcript variant 1
人 SCN4B (NM_001142348) cDNA克隆 transcript variant 2
人 SCN4B (NM_001142349) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

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