人 PRDM2 (NM_001007257) cDNA克隆

基本信息

Accession: NM_001007257
基因名称: PRDM2
基因别名: RIZ; KMT8; RIZ1; RIZ2; MTB-ZF; HUMHOXY1
基因描述: Homo sapiens PR domain containing 2, with ZNF domain (PRDM2), transcript variant 3, mRNA.
种属: Human
CDS区长度: 4446 (查看编码区序列)
翻译后氨基酸长度: 1481 (查看氨基酸序列)
Transcript Variant: This variant (3) is shorter at the 5' end and differs in the 3' UTR and coding region compared to variant 1. Expression of this transcript is under the control of an internal promoter in the gene (PMID: 9006946), which is why it is shorter at the 5' end than variant 1. The resulting isoform (c, also called RIZ2) is shorter at the N-terminus and has a distinct C-terminus compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G164998 人 PRDM2 (NM_001007257) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PRDM2 (NM_012231) cDNA克隆 transcript variant 1
人 PRDM2 (NM_015866) cDNA克隆 transcript variant 2
人 PRDM2 (NM_001007257) cDNA克隆 transcript variant 3
人 PRDM2 (NM_001135610) cDNA克隆 transcript variant 4

基因简介

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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