人 JAM3 (NM_001205329) cDNA克隆

Accession: NM_001205329
基因名称: JAM3
基因别名: JAMC; JAM-2; JAM-3; JAM-C
基因描述: Homo sapiens junctional adhesion molecule 3 (JAM3), transcript variant 2, mRNA.
种属: Human
CDS区长度: 780 (查看编码区序列)
翻译后氨基酸长度: 259 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
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G166286 人 JAM3 (NM_001205329) cDNA克隆 pDONR223 2ug质粒 点击询价

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]