人 API5 (NM_001142931) cDNA克隆

基本信息

Accession: NM_001142931
基因名称: API5
基因别名: AAC11; AAC-11
基因描述: Homo sapiens apoptosis inhibitor 5 (API5), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1353 (查看编码区序列)
翻译后氨基酸长度: 450 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform c) lacks an internal segment in the N-terminal region and has a shorter and distinct C-terminus, compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G166813 人 API5 (NM_001142931) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 API5 (NM_001142930) cDNA克隆 transcript variant 1
人 API5 (NM_006595) cDNA克隆 transcript variant 2
人 API5 (NM_001142931) cDNA克隆 transcript variant 3
人 API5 (NM_001243747) cDNA克隆 transcript variant 5

基因简介

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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