人 CDK11B (NM_033489) cDNA克隆

基本信息

Accession: NM_033489
基因名称: CDK11B
基因别名: p58; PK58; CDK11; CLK-1; CDC2L1; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110
基因描述: Homo sapiens cyclin-dependent kinase 11B (CDK11B), transcript variant 5, mRNA.
种属: Human
CDS区长度: 2247 (查看编码区序列)
翻译后氨基酸长度: 748 (查看氨基酸序列)
Transcript Variant: This variant (5) contains an additional 5' internal fragment and lacks an internal coding region when compared to variant 1. The additional fragment leads to a translation frame shift. The resulting protein has a unique first 3 aa and a 37 aa truncation at the N-terminus, as well as lacks an internal fragment, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G167968 人 CDK11B (NM_033489) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CDK11B (NM_001787) cDNA克隆 transcript variant 1
人 CDK11B (NM_033490) cDNA克隆 transcript variant 6
人 CDK11B (NM_033486) cDNA克隆 transcript variant 2
人 CDK11B (NM_033487) cDNA克隆 transcript variant 3
人 CDK11B (NM_033489) cDNA克隆 transcript variant 5

基因简介

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]

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