人 LRBA (NM_001199282) cDNA克隆

基本信息

Accession: NM_001199282
基因名称: LRBA
基因别名: BGL; LBA; CDC4L; CVID8; LAB300
基因描述: Homo sapiens LPS-responsive vesicle trafficking, beach and anchor containing (LRBA), transcript variant 1, mRNA.
种属: Human
CDS区长度: 8556 (查看编码区序列)
翻译后氨基酸长度: 2851 (查看氨基酸序列)
Transcript Variant: This variant (1) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 2. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 2.

订购信息

产品编号 产品名称 载体 规格 价格
G168002 人 LRBA (NM_001199282) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 LRBA (NM_001199282) cDNA克隆 transcript variant 1
人 LRBA (NM_006726) cDNA克隆 transcript variant 2

基因简介

The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

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