人 RANBP2 (NM_006267) cDNA克隆

Accession: NM_006267
基因名称: RANBP2
基因别名: ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358
基因描述: Homo sapiens RAN binding protein 2 (RANBP2), mRNA.
种属: Human
CDS区长度: 9675 (查看编码区序列)
翻译后氨基酸长度: 3224 (查看氨基酸序列)
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G170037 人 RANBP2 (NM_006267) cDNA克隆 pDONR223 2ug质粒 点击询价

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]