人 XRN1 (NM_001282859) cDNA克隆

基本信息

Accession: NM_001282859
基因名称: XRN1
基因别名: SEP1
基因描述: Homo sapiens 5'-3' exoribonuclease 1 (XRN1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1380 (查看编码区序列)
翻译后氨基酸长度: 459 (查看氨基酸序列)
Transcript Variant: This variant (4) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a shorter and distinct C-terminus, compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G172280 人 XRN1 (NM_001282859) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 XRN1 (NM_019001) cDNA克隆 transcript variant 1
人 XRN1 (NM_001282857) cDNA克隆 transcript variant 3
人 XRN1 (NM_001282859) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

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