人 AKR1C2 (NM_001135241) cDNA克隆

基本信息

Accession: NM_001135241
基因名称: AKR1C2
基因别名: DD; DD2; BABP; DDH2; HBAB; HAKRD; MCDR2; SRXY8; AKR1C-pseudo
基因描述: Homo sapiens aldo-keto reductase family 1, member C2 (AKR1C2), transcript variant 3, mRNA.
种属: Human
CDS区长度: 420 (查看编码区序列)
翻译后氨基酸长度: 139 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR, lacks multiple 3' coding exons, and includes a different terminal exon compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G101190 人 AKR1C2 (NM_001135241) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 AKR1C2 (NM_001354) cDNA克隆 transcript variant 1
人 AKR1C2 (NM_205845) cDNA克隆 transcript variant 2
人 AKR1C2 (NM_001135241) cDNA克隆 transcript variant 3

基因简介

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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