The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
人 GRB2 (NM_203506) cDNA克隆
| Accession: | NM_203506 |
|---|---|
| 基因名称: | GRB2 |
| 基因别名: | ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2 |
| 基因描述: | Homo sapiens growth factor receptor-bound protein 2 (GRB2), transcript variant 2, mRNA. |
| 种属: | Human |
| CDS区长度: | 531 (查看编码区序列) |
| 翻译后氨基酸长度: | 176 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. It encodes the shorter isoform (2) that lacks an internal segment, as compared to isoform 1. |
| 人 GRB2 (NM_002086) cDNA克隆 | transcript variant 1 |
| 人 GRB2 (NM_203506) cDNA克隆 | transcript variant 2 |
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