人 ICAM4 (NM_001039132) cDNA克隆

基本信息

Accession: NM_001039132
基因名称: ICAM4
基因别名: LW; CD242
基因描述: Homo sapiens intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (ICAM4), transcript variant 3, mRNA.
种属: Human
CDS区长度: 819 (查看编码区序列)
翻译后氨基酸长度: 272 (查看氨基酸序列)
Transcript Variant: This variant (3) uses an alternate acceptor splice site at exon 2 which results in a frameshift and translation termination further downstream, compared to variant 1. The encoded isoform (3) thus has the same N-terminus, but has alterations to the C-terminal second Ig-like C2-type domain, the transmembrane domain, and the cytoplasmic domain, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G103727 人 ICAM4 (NM_001039132) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ICAM4 (NM_001544) cDNA克隆 transcript variant 1
人 ICAM4 (NM_022377) cDNA克隆 transcript variant 2
人 ICAM4 (NM_001039132) cDNA克隆 transcript variant 3

基因简介

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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