人 RBBP8 (NM_203292) cDNA克隆

基本信息

Accession: NM_203292
基因名称: RBBP8
基因别名: RIM; COM1; CTIP; JWDS; SAE2; SCKL2
基因描述: Homo sapiens retinoblastoma binding protein 8 (RBBP8), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2604 (查看编码区序列)
翻译后氨基酸长度: 867 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G104506 人 RBBP8 (NM_203292) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RBBP8 (NM_002894) cDNA克隆 transcript variant 1
人 RBBP8 (NM_203291) cDNA克隆 transcript variant 2
人 RBBP8 (NM_203292) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

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