人 SIRT2 (NM_001193286) cDNA克隆

基本信息

Accession: NM_001193286
基因名称: SIRT2
基因别名: SIR2; SIR2L; SIR2L2
基因描述: Homo sapiens sirtuin 2 (SIRT2), transcript variant 3, mRNA.
种属: Human
CDS区长度: 705 (查看编码区序列)
翻译后氨基酸长度: 234 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, and also lacks a big segment in the 3' region, resulting in a frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, and a shorter and different C-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G106103 人 SIRT2 (NM_001193286) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SIRT2 (NM_012237) cDNA克隆 transcript variant 1
人 SIRT2 (NM_030593) cDNA克隆 transcript variant 2
人 SIRT2 (NM_001193286) cDNA克隆 transcript variant 3

基因简介

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

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