人 SETMAR (NM_001276325) cDNA克隆

基本信息

Accession: NM_001276325
基因名称: SETMAR
基因别名: Mar1; HsMar1; METNASE
基因描述: Homo sapiens SET domain and mariner transposase fusion gene (SETMAR), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1098 (查看编码区序列)
翻译后氨基酸长度: 365 (查看氨基酸序列)
Transcript Variant: This variant (4) lacks the terminal exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1. This isoform 3 lacks the mariner transposase domain found in isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G106106 人 SETMAR (NM_001276325) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SETMAR (NM_006515) cDNA克隆 transcript variant 1
人 SETMAR (NM_001243723) cDNA克隆 transcript variant 2
人 SETMAR (NM_001276325) cDNA克隆 transcript variant 4

基因简介

This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

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