人 CBFA2T2 (NM_001032999) cDNA克隆

基本信息

Accession: NM_001032999
基因名称: CBFA2T2
基因别名: EHT; p85; MTGR1; ZMYND3
基因描述: Homo sapiens core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1788 (查看编码区序列)
翻译后氨基酸长度: 595 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 2. The resulting isoform (MTGR1c) has a shorter and distinct N-terminus compared to isoform MTGR1b.

订购信息

产品编号 产品名称 载体 规格 价格
G107046 人 CBFA2T2 (NM_001032999) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CBFA2T2 (NM_005093) cDNA克隆 transcript variant 2
人 CBFA2T2 (NM_001032999) cDNA克隆 transcript variant 3
人 CBFA2T2 (NM_001039709) cDNA克隆 transcript variant 4

基因简介

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

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