人 CBFA2T3 (NM_175931) cDNA克隆

基本信息

Accession: NM_175931
基因名称: CBFA2T3
基因别名: ETO2; MTG16; MTGR2; ZMYND4
基因描述: Homo sapiens core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1704 (查看编码区序列)
翻译后氨基酸长度: 567 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame coding exon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (2) that lacks an internal segment and has a shorter N-terminus, compared to isoform 1. Variant 2 is also known as MTG16b.

订购信息

产品编号 产品名称 载体 规格 价格
G166906 人 CBFA2T3 (NM_175931) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CBFA2T3 (NM_005187) cDNA克隆 transcript variant 1
人 CBFA2T3 (NM_175931) cDNA克隆 transcript variant 2

基因简介

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

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